Dermal penetration and systemic level
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Establishing Limits for Dermal Absorption of Elemental Impurities | Pharmaceutical Technology
5 Sep In vivo analysis of dermal and systemic absorption of silver nanoparticles through healthy human skin. Silver serum levels were also analysed before and after application of the dressing. RESULTS: In addition, there was no demonstrable rise in serum silver levels post-treatment with the silver dressing.
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Description:Part E uses a consistent methodology for assessing the exposures from the dermal pathway for Superfund human health risk assessments. Our results suggest that silver nanoparticles are able to penetrate intact human skin in vivo beyond the stratum corneum and can be found as deep as the reticular dermis. Even when a formulation has been deliberately designed to facilitate transport across the dermal barrier, exposure levels are typically a fraction of those obtained when the drug is delivered by injection. Current guidelines for exposure limits, however, are based on oral, parenteral, or inhalation exposure and do not adequately address other routes, such as dermal exposure.